Aripiprazole for the treatment of irritability associated with autism

Emerging role of aripiprazole for treatment of irritability associated with autistic disorder in children and adolescents

Autistic disorder is a largely misunderstood and difficult to treat neurodevelopmental disorder. Three core domains of functioning are affected by autistic disorder, ie, socialization, communication, and behavior. Signs of autistic disorder may be present early, but are frequently overlooked, resulting in a delay in its diagnosis and a subsequent delay in treatment. No one definitive therapy is...

Efficacy and Safety of Aripiprazole for Treatment of Irritability in Children with Autistic Disorder: An Open-Label Study

Aripiprazole for treating irritability in children & adolescents with autism: a systematic review

BACKGROUND & OBJECTIVES No clear therapeutic benefits of antipsychotics have been reported for the treatment of behavioural symptoms in autism. This systematic review provides an assessment of evidence for treating irritability in autism by aripiprazole. METHODS The databases of MEDLINE/PubMed and Google Scholar were searched for relevant articles about the effect of aripiprazole in children ...

Aripiprazole decreases irritability in 12 out of 14 youth with autism spectrum disorders.

A utism is a neurodevelopment disorder characterized by lifelong impairments. Youth with autism spectrum disorders (ASDs) are often prescribed medication treatments to help with Both aripiprazole and risperidone have been approved by the United States Food and Drug Administration (FDA) to treat the irritability of autism, and short-term studies have demonstrated safety and preliminary efficacy....

Lurasidone for the Treatment of Irritability Associated with Autistic Disorder

The aim of this study was to evaluate the short-term efficacy and safety of lurasidone in treating irritability associated with autistic disorder. In this multicenter trial, outpatients age 6-17 years who met DSM-IV-TR criteria for autistic disorder, and who demonstrated irritability, agitation, and/or self-injurious behaviors were randomized to 6 weeks of double-blind treatment with lurasidone...